Orthopedic Bioengineering
Research Laboratory

Qin Y-X., Lam H. Ferreri S, Rubin C. (2010): Dynamic Skeletal Muscle Stimulation and its Potential in Bone Adaptation. J Musculoskeletal and Neuronal Interactions. March, 10(1):12-24.

Lam H., Brink, P., Qin Y-X. (2010): Skeletal Nutrient Vascular Adaptation Induced by External Oscillatory Intramedullary Fluid Pressure Intervention. J Ortho Surg Res, 5(1):18.

Ba X., Rafailovich M., Meng Y., Pernodet N., Wirick S., Füredi-Milhofer H., Qin Y-X, DiMasi E. (2010): Complementary effects of multi-protein components on biomineralization in vitro. J Struct Biology. 170(1):83-92.

Zhang Z, Yan Y, Lim Y, Tang D, Xie R, Chen A, Tai T, Harris SE, Xing L, Qin Y-X, Chen D (2009): BMP-2 Modulates β-Catenin Signaling through Stimulation of Lrp5 Expression and Inhibition of β-TrCP Expression in Osteoblasts. J Cellular Biochem, Nov 1;108(4):896-905.

Lin, W., Xia, Y. and Qin, Y-X. (2009): Characterization of the trabecular bone structure using frequency modulated ultrasound pulse. J Acoust Soc Am. Jun;125(6):4071-7

Ozcivici E., Luu YK, Adler B, Qin Y-X, Rubin J, Judex S, Rubin CT (2009): Mechanical Signals as Anabolic Agents in Bone. Nat Rev Rheum. Jan;6(1):50-9.

Qin Y-X., Lam H. (2009): Intramedullary Pressure and Matrix Strain Induced by Oscillatory Skeletal Muscle Stimulation and its Potential in Adaptation. J Biomech, 42(2):140-145.

Qin, Y-X., Xia, Y., Lin, W., Mittra, E., Rubin, C., Gruber, B. (2008): Noninvasive Ultrasound Imaging for Bone Quality Assessment using Scanning Confocal Acoustic Diagnosis, mCT, DXA Measurements, and Mechanical Testing. LNCS, ISSN:0302-9743 (p)/1611-3349 (online). Dec, 4901:216-233.

Mittra, E., Rubin, C., Gruber, B. and Qin, Y-X. (2008): Evaluation of trabecular mechanical and microstructural properties in human calcaneal bone of advanced age using mechanical testing, mCT, and DXA. J Biomech, 41:368-375.

Ozcivici E, Ferreri S, Qin YX, Judex S (2008): Determination of bone's mechanical matrix properties by nanoindentation. Methods Mol Biol. 455:323-34

Meng Y., Qin Y-X., DiMasi E., Ba X., Rafailovich M., Pernodet N. (2008): Biomineralization of a Self-Assembled Extracellular Matrix for Bone Tissue Engineering. Tis Eng, Part A, 15(2):355-366.

Lam H., Qin Y-X. (2008): Biomineralization of a Self-Assembled Extracellular Matrix for Bone Tissue Engineering. Bone, 43(6):1093-100.

Qin, Y-X., Xia, Y., Lin, W., Mittra, E., Rubin, C., Gruber, B. (2007): Noninvasive Ultrasound Imaging for Bone Quality Assessment using Scanning Confocal Acoustic Diagnosis, mCT, DXA Measurements, and Mechanical Testing. LNCS, ISSN:0302-9743 (p)/1611-3349 (online). Dec, 4901:216-233.

Xia, Y., Lin, W. and Qin, Y-X. (2007): Bone Surface Topology Mapping and its Role in Trabecular Bone Quality Assessment using Scanning Confocal Ultrasound. Osteoporosis Intl, Jul;18(7):905-13.

Ni, Q., De Los Santos, A, Lam, H., Qin, Y-X. (2007): Assessment of Simulated and Functional Disuse on Cortical Bone by Nuclear Magnetic Resonance. Adv in Space Res, 40:1703-10.

Mittra, E., Akella, S. and Qin, Y-X. (2006): The effects of embedding material, loading rate and magnitude, and penetration depth in nanoindentation of trabecular bone. J Biomed Mat Res, Part-A, Oct;79(1):86-93.

Lin, W. Mittra, E. and Qin, Y-X. (2006): Determination of ultrasound phase velocity in trabecular bone using time dependent phase tracking technique. J Biomech Eng, Feb., 128(1):24-29.

Mankani, M.H., Kuznetsov, S.A., Shannon, B., Nalla, R.K., Ritchie, R.O., Qin, Y., Robey, P.G. (2006): Canine Cranial Reconstruction Using Autologous Bone Marrow Stromal Cells. Am J Pathology, Vol. 168, No. 2, Feb.

Qin, Y-X., Lam, H.Y., Orzechowski, L. (2006): Anabolic Fluid Flow Stimulation is responsible for Bone Formation as a Manner of Specific Frequency and Magnitude. Int’l Proceeding of 5th World Congress of Biomech, Ed. By D. Liepsch. Medimond S.r.l., ISBN 88-7587-270-8, pg: 45-49.

Rubin, C. T., Judex, S., Qin, Y-X. (2006): Low-level mechanical signals and their potential as a non-pharmacological intervention for osteoporosis. Age and Ageing, 35-S2: ii26–ii30.

Busa, B., Miller, L., Qin, Y-X., Rubin, C., Judex, S. (2005): Rapid Establishment of Chemical and Mechanical Properties during Lamellar Bone Formation. Cal Tis Intl’, Dec; 77(6):386-94.

Xia, Y., Lin, W. and Qin, Y-X. (2005): The Influence Of Cortical End-Plate On Broadband Ultrasound Attenuation Measurements At The Human Calcaneus Using Scanning Confocal Ultrasound. J Acoustic Soc of Am, 118 (3):1801-1807.

Mittra, E., Rubin, C. and Qin, Y-X. (2005): Interrelationship of trabecular mechanical and microstructural properties in sheep trabecular bone. J Biomech, 38(6):1229-37.

Qin, Y-X., Kaplan, T., Saldanah, A. and Rubin, C.T. (2003): Fluid Pressure Gradients, Arising from Oscillations in Intramedullary Pressure, is Correlated with the Formation of Bone and Inhibition of Intracortical Porosity. J Biomech, Oct;36(10):1427-37.

Judex, S., Boyd, S., Qin, Y-X, Miller, L., Müller, R., Rubin, C. (2003) Combining High-Resolution MicroCT with Material Composition to Define the Quality of Bone Tissue. Current Osteoporosis Reports. 1:11-19

Judex, S., Boyd. S., Qin, Y-X., Turner, S., Ye, K., Müller, R., Rubin, C. (2003): Adaptation of trabecular bone to low magnitude vibrations result in increased stiffness and more uniform stress and strain under load. Annals Biomed Eng, 31(1), 12-20.

Qin, Y-X., Lin, W., and Rubin, C.T. (2002): The Pathway of Bone Fluid Flow as Defined by In Vivo Intramedullary Pressure and Streaming Potential Measurements, Annals Biomed Eng, 30:693-702.

Rubin, C. T., Turner, S., Muller, R., Mittra, E., McLeod, K., Lin, W., and Qin, Y-X. (2002): Quantity and Quality of Trabecular Bone in the Femur are Enhanced by a Strongly Anabolic, Noninvasive Mechanical Intervention. J Bone Min Res, 17(2): 349-357.

Beck, B., Qin, Y-X., McLeod, K.J. and Otter, M (2002): On the relationship between streaming potential and strain in an in vivo bone preparation. Calcif Tiss Intl, 71(4):335-343.

Lin, W., Qin, Y-X., and Rubin, C.T. (2001): Ultrasonic Wave Propagation in Trabecular Bone Predicted by the Stratified Model. Annals Biomed Eng, 29(9): 781-790.

Rubin, C. T., Sommerfeldt, D. W., Judex, S. and Qin, Y-X. (2001): Inhibition of Osteopenia by Low Magnitude, High Frequency Mechanical Stimuli. Drug Discovery Today, 6:16:848-858.

Demes, B., Qin, Y-X., Stern, J. T. Jr., Larson, S. G., Rubin, C.T. (2001): Patterns of strain in the macaque tibia during functional activity. Am J Physcial Anthropology, 116:257-265.

Khalsa, P.S., Zhang, C., & Qin, Y-X. (2000): Encoding of Location and Intensity of Noxious Indentation into Rat Skin by Spatial Populations of Cutaneous, Mechano-Nociceptors. J. Neurophysiology, 83:3049-3061.

Otter, M.W., Qin, Y-X., Rubin, C.T. and McLeod, K.J. (1999): Does Bone Perfusion/Reperfusion Initiate Bone Remodeling and the Stress Fracture Syndrome? Medical Hypotheses,53(5):363-368.

Qin, Y-X., Rubin, C.T., & McLeod, K.J. (1998): Non-linear Dependence of Loading Intensity and Cycle Number in the Maintenance of Bone Mass and Morphology. J. Orthop. Res. 16:482-489.

McLeod, K.J., Rubin, C.T., Otter, M.W. and Qin, Y-X. (1998): Skeletal Cell Stresses and Bone Adaptation. Am. J. Med. Sci., 316:176-183.

Qin, Y., McLeod, K., Otter, M., & Rubin, C. (1997): Intracortical Pore Fluid Pressure and Gradients Generated by Dynamic Loading and Their Potential Role in Bone Adaptation. Annals of Biomed. Eng., 25:449-460

Fritton, J.C., Rubin, C.T., Qin, Y-X, and McLeod, K.J. (1997): Vibration in the Skeleton: I. Development of a Resonance-Based Whole Body Vibration Device. Annals of Biomedical Engineering 25:6-12.

Qin, Y-X., McLeod, K.J., Guilak, F., Chiang, F-P and Rubin, C.T. (1996): Correlation of Bony Ingrowth to the Distribution of Stress and Strain Parameters Surrounding a Porous-Coated Implant. J. Ortho. Res. 14:862-870.

Rubin, C.T., Gross, T., Qin, Y-X., Fritton, S., Guilak, F., and McLeod, K.J. (1996): Differentiation of the Bone Tissue Remodeling Response to Axial and Torsional Loading in the Turkey Ulna. J. Bone Joint Surg. 78-A:1523-1533.

Qin, Y-X., Zhu, L., Young, C. and Hsu, W. (1988): PEF-1 Type Occlusal Force Meter and Its Clinical Applications. Chinese J. Stomatology, 8:18-22.

Qin, Y-X., Wang, W., and Shao, Q. (1987): The Method of Ultrasonic Convergency for the Blood Flow Measurement with Doppler Ultrasound in the Small Vessel on Oral and Maxillofacial Regions. Chinese J. Biomedic. Eng., 6:132-136.