Javed Butler, M.D. Professor and Chief, Division of Cardiology, Stony Brook University Hospital
Towards Understanding the Biomechanical Mechanisms Underlying Clinical Complications in Transcatheter Aortic Valve Replacement Email:Javed Butler
Luis Gruberg, M.D. Professor, Division of Cardiology, Stony Brook University Hospital
Patient-based modeling and diagnostics of vulnerable plaques to determine risk of rupture; Towards Understanding the Biomechanical Mechanisms Underlying Clinical Complications in Transcatheter Aortic Valve Replacement Email:Luis Gruberg
Jolyon Jesty, D. Phil. Professor Emeritus of Medicine, Division of Hematology & Oncology, Stony Brook University Medical Center
Control mechanisms of hemostasis and the pathways of blood coagulation form the crux of Jesty's research. Collaborative projects with the Biofluids Research Group study the effects of prosthetic devices on platelet activation. Towards this effect, a chemically modified prothrombinase-based assay was developed to quantify level of platelet activation.
Smadar Kort, M.D. Professor, Department of Medicine, and Director, Cardiovascular Imaging, Stony Brook University Hospital
Towards Understanding the Biomechanical Mechanisms Underlying Clinical Complications in Transcatheter Aortic Valve Replacement Email:Smadar Kort
Nicos Labropoulos, Ph.D., RVT Professor and Director of Non-Invasive Vascular Laboratory, Department of Surgery, Stony Brook University Hospital
Patient-based modeling and diagnostics of abdominal aortic aneurysms (AAA) and vulnerable plaques Email:Nicos Labropoulos
Vinay Tak, M.D. Professor, Division of Cardiac Surgery, Department of Surgery, Stony Brook University Hospital
Towards Understanding the Biomechanical Mechanisms Underlying Clinical Complications in Transcatheter Aortic Valve Replacement Email:Vinay Tak
Kavitha Yaddanapudi, M.D. Professor, Division of Advanced Cardiac Imaging, Department of Radiology, Stony Brook University Hospital
Towards Understanding the Biomechanical Mechanisms Underlying Clinical Complications in Transcatheter Aortic Valve Replacement Email:Kavitha Yaddanpudi
Morteza Gharib, Ph.D. Hans W. Liepmann Professor of Aeronautics and Bioengineering, Engineering and Applied Sciences, California Institute of Technology
Collaboration in a research project concerning quantitative flow visualization using Digital Particle Image Velocimetry (DPIV)
John Ricotta, M.D. Chair, Department of Surgery, MedStar Washington Hospital Center, Washington, D.C.
Patient-based modeling and diagnostics of abdominal aortic aneurysms (AAA) and vulnerable plaques
Marvin J. Slepian, M.D. Professor and Director of Interventional Cardiology, Sarver Heart Center, University of Arizona Chairman, Chief Scientific and Medical Officer, SynCardia Systems, Inc.
Testing the thrombogenic performance of the Cardiowest temporary Total Artificial Heart (TAH-t)
Shmuel Einav, Ph.D. Director of Medical Technologies Division, CEWIT, Associate Dean and Professor, College of Engineering and Applied Sciences, Stony Brook University; Emeritus Professor of Biomedical Engineering, Tel-Aviv University, Tel-Aviv, Israel
Dr. Einav is best known for his studies on blood flow through heart valves, coronary circulation, blood-tissue interaction, and flow and turbulent characteristics in occluded arteries. The focus of his research is the role of hemodynamics in the initiation of atherosclerosis, the dynamics of cardiovascular flows, and the influence of flow and the associated shear stress on vascular endothelial biology. He is associated with the Biofluids Research Group in a collaboration to study thrombus formation in large blood vessels and devices. Email:Shmuel.Einav@stonybrook.edu
Food and Drug Administration (FDA), Rockville, MD.
HeartStat, Inc., Madison, CT. and Huntington, NY.
Innovia LLC, Miami, FL.
MicroMed Cardiovascular, Inc., Houston, TX.
Polynova Cardiovascular, Inc., Stony Brook, NY.
St. Jude Medical, St. Paul, MN.
SynCardia Systems, Inc., Tuscon, AZ.
Thoratec Corporation, Pleasanton, CA.
Past Academic Collaborations
Klaus Affeld, Ph.D. Professor, Biofluid Mechanics Group, Charité-Universitätsmedizin, Berlin, Germany
Collaboration in a research project to study flow induced thromboembolism in Left Ventricular Assist Devices (LVAD). Dr. Affeld, in addition to applying engineering knowledge to solving flow-related problems in medicine, and more specifically, cardiovascular mechanics, has developed two different heart assist systems - one implantable kind and another that is a partially implantable pneumatic heart assist system. The pneumatic heart assist system consists of an implantable part, the ventricle, and an extra corporal part, the driver. The Biofluids Research Group conducts experiments with this kind of LVAD obtained from his laboratory.
David Brown, M.D. Professor, Division of Cardiology, Stony Brook University Medical Center
Patient-based modeling and diagnostics of vulnerable plaques to determine risk of rupture
Glenn Gaudette, Ph.D. Associate Professor, Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA
Coronary artery disease generally leads to regional ischemia (no nutritive supply), resulting in a decrease in regional mechanical function. Currently, available techniques do not offer the high spatial resolution needed to determine the heterogeneous mechanical function of the heart. Glenn Gaudette's research is focused towards developing and optimizing a method to determine regional function in the heart. The method recently developed is a whole field technique that offers high spatial resolution and is used to investigate the effects of regional ischemia on heart function. Gaudette collaborated with the Biofluids Laboratory in a project concerned with effects of implantation techniques on thromboembolic rates in prosthetic heart valves.
Oded Gerber, M.D. Associate Professor of Clinical Neurology, Department of Neurology, Stony Brook University Medical Center
Collaboration in measuring high intensity transient signals (HITS) with Transcranial Doppler (TCD) to intercept free emboli formed by mechanical heart valves implanted in sheep.
Michael Guido, M.D. Associate Professor, Department of Neurology, Stony Brook University Medical Center
Collaboration in measuring high intensity transient signals (HITS) with Transcranial Doppler (TCD) to intercept free emboli formed by mechanical heart valves implanted in sheep.
Irvin B. Krukenkamp, M.D. Past Professor of Cardiothoracic Surgery, Director Stony Brook Heart Center, Department of Surgery, Stony Brook University Medical Center
Dr. Krukenkamp collaborated with the Biofluids Research Group in an effort to study the effects of implantation techniques on thromboembolic rates in prosthetic heart valves in vivo. He also performed surgery and valve implantation in animal models (sheep) used to measure platelet activation, thromboembolic rates, and other histological studies to better understand prosthetic valve function.
Foluso Ladeinde, Ph.D. Associate Professor, Mechanical Engineering, Stony Brook University
Ladeinde's research mainly involves the development of theoretical and specialized computational techniques for the solution of model problems in high-speed aerodynamics where combustion, heat transfer, and fluid dynamics in aerospace propulsion systems are the application areas. The Biofluids lab was involved with a joint project in which a finite difference scheme was used to form a grid for a physiological geometry that houses a bi-leaflet mechanical heart valve. This grid was imported into a fluid solver CFD software that would be capable of solving Large Eddy Simulations (LES) so that the small-scale turbulent fluctuations can be monitored closely and their effects on platelet activation can be studied in-depth.
Adam E. Saltman, M.D., Ph.D. Attending Thoracic Surgeon, Beth Israel Medical Center, Brooklyn, NY
Effects of implantation techniques on thromboembolic rates in prosthetic heart valves. In vivo experiments in sheep models.
Krishnamurthy Suresh, M.D. Assistant Professor, Division of Cardiology, Stony Brook University Medical Center
Dr. Suresh, Assistant Professor of Medicine, serves on the American Board of Internal Medicine in both the Internal Medicine and the Cardiovascular Diseases divisions. He collaborated with the Biofluids laboratory in a research project that is concerned with the effects of implantation techniques on thromboembolic rates in prosthetic heart valves. Specifically, he was involved with the in vivo sheep model experiments wherein he conducts Transesophageal Echocardiography (TEE).
Dahai Yu, Ph.D. Visiting Assistant Professor, Applied Math and Statistics, Stony Brook University
The research of Dahai Yu mainly concerns applications of computational mathematics to continuum mechanics (fluid / solid) and is fulfilled with a three-pronged approach to any problem: Computational Fluid Dynamics (CFD), Computational Solid Mechanics, and Numerical Methods. In a collaborative effort with the Biofluids laboratory, a code is being developed in order to achieve a Large Eddy Simulation (LES) of flow past a bi-leaflet mechanical heart valve so that the transient flow patterns and the onset of turbulence in the region of the leaflets can be better observed. This would aid in a deeper understanding of flow-induced platelet activation and the response of the platelet physiological system to mechanical stimuli such as shear stresses that exist in the normal circulation.
Marlene Zawin, M.D. Assistant Professor and Chief of Computed Tomography, Department of Radiology, Stony Brook University Medical Center
Patient-based modeling and diagnostics of abdominal aortic aneurysms (AAA) and vulnerable plaques
Tom Zimmerman, D.V.M., M.P.V.M., D.A.C.L.A.M. Director of Veterinary Services, Division of Laboratory Animal Resources, Stony Brook University
The Biofluids Research Group worked in close conjunction with the Division of Laboratory Animal Resources (DLAR) in conducting in vivo experiments with the sheep model, and is very thankful for their technical expertise.